The solution of clearing all preferences and restarting of course works, as it clears everything out and you start from scratch making settings for you apps.But then you are in for a long time of getting all the app preferences right again.BUT.. There is a better way, that allows you to keep you current settings and „switch“ them to the new version of Adobe (whatever).Save (backup) a copy of your Wacom settings. This file is for editing. (Save an extra copy with a different name, in case you mess up the XML file to be edited. :leicht_lächelndes_Gesicht: )Now edit the first backup file (default called „Backup.wacomprefs“) in a good text editor.

Quelle: Gelöst: Wacom applications specific shortcut aren’t workin… – Adobe Support Community – 7417956