We can also inject the ads via the the_content filter, in the main loop:
add_action( 'loop_start', 'wpse_141253_loop_start' );
function wpse_141253_loop_start( $query )
{
if( $query->is_main_query() )
{
add_filter( 'the_content', 'wpse_141253_the_content' );
add_action( 'loop_end', 'wpse_141253_loop_end' );
}
}
function wpse_141253_the_content( $content )
{
static $nr = 0;
if( 0 === ++$nr % 4 )
$content .= '
<div>------- MY AD HERE -------</div>
';
return $content;
}
function wpse_141253_loop_end()
{
remove_action( 'the_post', 'wpse_141253_the_content' );
}
















